McCallion is a surname. Notable people with the surname include:
Eddie McCallion (born 1979), Northern Irish footballer
Enda McCallion (born 1967), Irish film director
Hazel McCallion (born 1921), Canadian mayor
Mac McCallion (born 1950), Fijian rugby union coach
Marcus McCallion (born 1971), English graphic designer and typographer
Seamus McCallion, Irish rugby league player