McCaffrey is an Irish surname. It is found mostly in the Counties Fermanagh, Monaghan, Cavan and Tyrone in the north west of Ireland. Ballymccaffrey is a townland outside of Tempo in county Fermanagh. The surname is an Anglicised form of the Gaelic names Mac Gafraidh, Mac Gofraidh, which mean "son of Gafraidh", "son of Gofraidh". The Gaelic names are forms of the Old Norse Guðfróðr. Notable people with the surname include:
Anne McCaffrey (1926–2011), science fiction author
Billy McCaffrey (born 1971), American basketball player (brother of Ed and uncle of Christian)
Barry McCaffrey (born 1942), military analyst
Cam McCaffrey (born 1983), Canadian former professional ice hockey player
Christian McCaffrey (born 1996), American football player (son of Ed)
Ed McCaffrey (born 1968), American football player
Francis J. McCaffrey (1917–1989), New York politician from the Bronx
Francis J. McCaffrey, Jr. (1902–1972), New York politician and judge from Brooklyn
Frank McCaffrey, American college football All-American player
Lt. Col. George Herbert McCaffrey, of the Canicattì massacre
James McCaffrey (born 1960), American actor
James D. McCaffrey (born 1950), software researcher
Janice McCaffrey (born 1959), Canadian racewalker
John McCaffrey (disambiguation), several people
Pete McCaffrey (1938–2012), American basketball player
Stuart McCaffrey (born 1979), Scottish footballer