Mazzone is a surname. Notable people with the surname include:
A. David Mazzone, US lawyer
Adolfo Mazzone, Argentine comics artist
Carlo Mazzone, Italian football manager
Dora Mazzone, Venezuelan actress
Juan Rosario Mazzone, Argentine mayor
Leo Mazzone, US pitcher
Mario Mazzone, Argentine journalist
Noel Mazzone, US American football coach and player
Steven Mazzone, US mobster
Jason Mazzone, US American jurist