Mazel is a surname. Notable people with the surname include:
Eugène Mazel (1828–1890), French amateur botanist
Ilya Mazel (aka Ruvim Mazel, 1890–1967), Soviet painter
Isaak Mazel (1911–1945), Soviet chess master
Judy Mazel (1943–2007), American weight loss advocate and author of the The Beverly Hills Diet
Leo Mazel (1907–2000), Soviet-Russian musicologist
Maurice Mazel, prominent Chicago surgeon who founded Edgewater Hospital
Olivier Mazel (1858–1940), French Army general during World War I
Zvi Mazel (born 1939), Israeli diplomat
Mazel can also refer to:
Luc Maezelle (born 1931), Belgian comic artist
