Mazel is a surname. Notable people with the surname include:
Eugène Mazel (1828–1890), French amateur botanistIlya Mazel (aka Ruvim Mazel, 1890–1967), Soviet painterIsaak Mazel (1911–1945), Soviet chess masterJudy Mazel (1943–2007), American weight loss advocate and author of the The Beverly Hills DietLeo Mazel (1907–2000), Soviet-Russian musicologistMaurice Mazel, prominent Chicago surgeon who founded Edgewater HospitalOlivier Mazel (1858–1940), French Army general during World War IZvi Mazel (born 1939), Israeli diplomatMazel can also refer to:
Luc Maezelle (born 1931), Belgian comic artist