Mayhew is a surname of English origin, Norman French or biblical origins.
Augustus Mayhew (1826-1875), English journalist and author
Christopher Mayhew (1915-1997), British politician
Cicely Mayhew (1924-2016), British diplomat
Clarence W. W. Mayhew (1906-1994), architect
David R. Mayhew (born 1937), political scientist
David Mayhew (racing driver) (born 1982), American racing driver
Diane Youdale Mayhew (born 1970), English television personality
Donna Mayhew (born 1960), American javelin thrower
Edward Mayhew (1569-1625), English Benedictine
Experience Mayhew (1673-1758), New England missionary
Helen Mayhew, British radio presenter and producer
Henry Mayhew (1812-1887), English social researcher and reforming journalist
Horace Mayhew (1845-1926), British Mining Engineer
John Mayhew (disambiguation)
Jonathan Mayhew (1720-1766), American clergyman
Judith Mayhew Jonas (born 1950), New Zealand-born British lawyer and academic
Lauren C. Mayhew (born 1985), American singer and actress
Matthew Mayhew (1648-1710), Governor and Chief Magistrate of Martha's Vineyard
Martin Mayhew (born 1965), former National Football League (NFL) player and current general manager of the NFL Detroit Lions
Mike Mayhew (born 1980), New Zealand Stuckist artist
Patrick Mayhew, Baron Mayhew of Twysden (1929-2016), British barrister and politician
Peter Mayhew (born 1944), English-born United States actor
Robert Mayhew (1880-1971), Canadian politician and diplomat
Sara Mayhew (born 1984), Canadian writer and graphic artist
Thomas Mayhew (cabinet maker) (1736–1811), English cabinet maker
Thomas Mayhew (governor) (1593-1682), Governor of Massachusetts who established the first English settlement of Martha's Vineyard in 1642
Mayhew Beckwith (1798-1871), merchant and politician in Nova Scotia (in present day Canada)
Mayhew Folger (1774-1828), American whaler who rediscovered the Pitcairn Islands