Mayes is a surname. Notable people with the surname include:
Adrian Mayes (born 1980), American football playerAlan Mayes (born 1953), English footballerBernard Mayes, British-American lecturer and authorClifford Mayes (born 1953), American professor of educationClyde Mayes (born 1953), American professional basketball playerColin Mayes (born 1948), Canadian politicianDerrick Mayes (born 1974), American football playerFrances Mayes (born 1940), American university professor, poet, memoirist, essayist, and novelistIan Mayes, British journalist and editorJeff Mayes (born 1971), American politicianJoel B. Mayes (died 1891), Chief of the Cherokee NationJohnny Mayes (born 1947), Australian rugby league playerRichard Mayes (1922 - 2006), English stage and television actorRon Mayes (born 1954), American educator and authorRueben Mayes (born June 6, 1963), Canadian football playerRufus Mayes (born 1947), American football playerSamuel Houston Mayes, Chief of the Cherokee Nation from 1895 to 1899Sean Mayes (1949-1995), English rock musician and authorWendell Wise Mayes, Jr. (born 1924), American radio and cable television executiveWilliam Mayes, Jr., prominent pirate, proprietor of White Horse Tavern (Rhode Island)William Edward Mayes (1861 – 1952), English painter