May Henrietta Mukle (14 May 1880 – 20 February 1963) was a British cellist. She has been described as a "noted feminist cellist", and encouraged other women cellists. She was described in The Times as "in the very front rank of living violoncellists", and her obituary in The Times says of her: "by the turn of the century she was fully recognized not only as an outstanding musician but as one of the most remarkable cellists this country had produced."
Her instrument was built by Montagnana and bought for her by an anonymous donor.
Her portrait, painted by John Mansfield Crealock, is held in the museum of the Royal Academy of Music. The May Mukle Prize was founded in 1964 in her honour and is awarded each year to a cello student of the college.
Mukle was born in London and died at Cuckfield, Sussex, at the age of 82.