Maupin is a surname. Notable people with the surname include:
Armistead Maupin (born 1944), American writer
Audry Maupin (1972–1994), boyfriend of Florence Rey, involved in a 1994 shoot-out in Paris
Bennie Maupin (born 1940), musician
David Maupin, co-founder of Lehmann Maupin Gallery
Harry Maupin (1872–1952), baseball pitcher
Matt Maupin (1983–2004), U.S. soldier
Robert Lee Maupin (1918–1992), also known as Robert Beck or Iceberg Slim, author
Simon Maupin (before 1625–1668), French architect
Jim Maupin, aircraft manufacturer in the United States