Mattison is a surname. Notable people with the surname include:
Andrew Mattison (1948–2005), medical psychologist and researcherBryan Mattison (born 1984), American football guardDonald Mattison (1905–1975), American artistGreg Mattison (born 1949), American football coachHarry Mattison (born 1948), American photographerJenna Mattison (born 1976), American actress, screenwriter and producerLandy Mattison (born 1983), American soccer defenderMike Mattison, American musician and the lead vocalist of The Derek Trucks Band