Mathews is a surname. Notable persons with that surname include:
Alfred Augustus Mathews, vicar and Wales international rugby player, 1864-1946Angelo Mathews (born 1987), Sri Lankan Burgher cricketerArthur Mathews (writer), Irish comedy writerArthur Frank Mathews, American painterBill Mathews, Canadian geologistCarole Mathews, American actressCornelius Mathews, 19th-century American writerDavid Mathews, Loyalist mayor of New York, 1776-1783Eddie Mathews (1931–2001), Hall of Fame third baseman in Major League BaseballFrancine Mathews, American novelistGeorge Mathews (disambiguation), several peopleGregory Mathews, Australian amateur ornithologistHarry Mathews (1930–2017), American authorHenry M. Mathews, governor of West Virginia, 1877-1881James Mathews (disambiguation), several peopleJay Mathews, author, education reporter and online columnist with the Washington PostJessica Mathews, president of the Carnegie Endowment for International PeaceJon Mathews, academicJonathan Mathews, baseball coachKevin Mathews, Singaporean musician and songwriterLloyd Mathews, British naval officer, politician and abolitionistMarlene Mathews, Australian sprinterMax Mathews, computer music pioneerRobert L. Mathews, American football player and coachRoss Mathews, American television personalitySampson Mathews, politician, Revolutionary War soldierSylvia Mathews Burwell, President of the Global Development Program of the Bill and Melinda Gates FoundationThomas Mathews, Royal Navy admiral, 1676-1751Vera Laughton Mathews, Director of the Women's Royal Naval Service from 1940 until 1946Walter J. Mathews, American architectWilliam Mathews (disambiguation), several people