Masterson is a surname. Notable people with the surname include:
Bat Masterson (1853-1921), gunfighter, lawman, sports writer
Chase Masterson (born 1963), American actress
Christopher Masterson (born 1980), American actor
Danny Masterson (born 1976), American actor, older brother of Christopher Masterson
Fay Masterson (born 1974), actress
James F. Masterson (1926-2010), American psychiatrist
Justin Masterson (born 1985), American baseball player
Kelly Masterson, American screenwriter.
Kleber S. Masterson, Vice Admiral U.S. Navy who headed up the Bureau of Naval Weapons
Martha Gay Masterson (1837–1916), American settler and diarist
Mary Stuart Masterson (born 1966), American actress
Paul Masterson, music producer
Rod Masterson (1945-2013), American actor
Valerie Masterson (born 1937), English opera singer
Walt Masterson (1920-2008), American baseball pitcher
Wayne Masterson (1959-1991), British scientist
