Massaquoi is a surname. Notable people with the surname include:
Hans Massaquoi (1926–2013), American journalist and writer
Jonathan Massaquoi (born 1988), American football player
Lamin Massaquoi (born 1978), Sierra Leonean footballer
Mohamed Massaquoi (born 1986), American football player
Roland Massaquoi, Liberian politician
Tim Massaquoi (born 1982), American football player