Trade names Masivet, Kinavet CAS Number 790299-79-5 ChemSpider 8250179 | ATC code L01XE22 (WHO) PubChem CID 10074640 Molar mass 498.64 g/mol | |
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AHFS/Drugs.com International Drug Names | ||
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.
Masitinib is being studied for several human conditions including cancers, Alzheimer, Multiple Sclerosis, Mastocytosis, and Amyotrophic Lateral Sclerosis. It is being studied in Europe for orphan diseases.
Mechanism of action
Masitinib inhibits the receptor tyrosine kinase c-Kit which is displayed by various types of tumour. It also inhibits the platelet derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR).