Masatsugu (written: 正次, 正継, 昌次, 雅継, 将嗣, 政嗣, 将次 and 政次) is a masculine Japanese given name. Notable people with the name include:
Abe Masatsugu (阿部 正次) (1569–1647), Japanese daimyō
Hajikano Masatsugu (初鹿野 昌次) (1545–1624), Japanese samurai
Heki Danjō Masatsugu (日置 弾正 政次) (1443–1502), Japanese warrior
Ishida Masatsugu (石田 正継) (died 1600), Japanese samurai
Masatsugu Kawachi (川内 将嗣) (born 1985), Japanese boxer
Masatsugu Morofuji (諸藤 将次) (born 1985), Japanese golfer
Nijō Masatsugu (二条 政嗣) (1443–1480), Japanese noble
Masatsugu Suzuki, Japanese-American physicist
Tsuchiya Masatsugu (土屋 昌次) (1544–1575), Japanese samurai
Yoshikaze Masatsugu (嘉風 雅継) (born 1982), Japanese sumo wrestler