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The Mary Prentiss Inn has historic roots that reach as far back as 1843 and has transformed from a home on Prentiss Street to a Cambridge, Massachusetts inn.
In 1843 the home was built by architect William A. Saunders as a wedding gift to his son, William, and his wife, Mary Prentiss. The home was built in the Neo-classical design during the popular Greek revival of 19th century in the United States of America. The Saunders resided at the home for 55 years. The building is on the U.S. National Register of Historic Places as the William Saunders House.
During its lifetime the building's vocation went from a home to hostelry to a nursing home. In 1991, it was bought by local artist Charlotte Forsythe who turned it into the hotel that it is today.