Mario Hernández may refer to:
Mario Hernández (fashion house), a Colombian fashion house
Mario Casanova Clemente Hernández (1924–2013), Puerto-Rican musician (see Mario Hernández at es.Wikipedia)
Mario Hernández (film director) (born 1936), Mexican film director and screenwriter
Mario Hernandez (comics) (born 1953), American writer, artist and comics publisher
Mario Fernando Hernández (1966–2008), Honduran politician
Mario Hernández Lash (born 1979), Mexican football defender