Margulies (rarely Margolyes) is a surname that, like its variants shown below, is derived from the Ashkenazi Hebrew pronunciation of the Hebrew word מרגליות (Israeli Hebrew [maɹgali'jot]), meaning 'pearls,' and may refer to:
Ben Margulies, songwriter and record producer
David Margulies (1937-2016), American actor
Donald Margulies, American playwright
Jimmy Margulies, award-winning editorial cartoonist
Joseph Margulies (1896-1984), a Vienna-born American painter and printmaker
Joseph Margulies, American attorney and law professor
Julianna Margulies, (born 1966), American actress
Lazar C. Margulies, (1895-1982) physician and inventor of a type of Intrauterine device
Leo Margulies, American editor and publisher
Martin Margulies (born 1948), real name of American musician/film producer Johnny Legend
Roni Margulies (born 1955), Turkish poet and activist
Samuel Hirsch Margulies (1858-1922), rabbi and Jewish scholar
Miriam Margolyes (born 1941), British-Australian actress
Ian Rankin chose Margulies as the name of an old Scottish Christian family in his novel Dead Souls.
