Margarethe is a feminine given name, related to Margaret. People bearing the name include:
Archduchess Margarethe Klementine of Austria (1870-1955), Archduchess of Austria and Princess of Bohemia, Hungary and TuscanyMargarethe Arndt-Ober (1885-1971), German operatic contraltoMargarethe Cammermeyer (born 1942), Washington National Guard colonel honorably discharged for disclosing she was a lesbianMaria Margarethe Danzi (1768-1800), German composer and sopranoMargarethe Faas-Hardegger (1882–1963), Swiss women's rights activist and trade unionistMargarethe von Oven (1904-1991), German accomplice in the 20 July plot to assassinate HitlerMargarethe von der Saale (1522–1566), German morganatic spouse by bigamy to Philip I, Landgrave of HesseMargarethe Schreinemakers (born 1958), German television presenter, talk show host and journalistMargarethe Lenore Selenka (1860-1922), German zoologist, anthropologist, feminist and pacifistMargarethe Siems (1879–1952), German operatic soprano and voice teacherMargarethe Stockhausen (1803–1877), opera singer from AlsaceMargarethe von Trotta (born 1942), German film director