Marchetti is an Italian surname. Notable people with the surname include:
Alberto Marchetti (born 1954), Italian professional football playerAlessandro Marchetti (aircraft engineer) (1884–1966), Italian aircraft engineerAlessandro Marchetti (mathematician) (1633–1714), Italian mathematicianAssunta Marchetti (1871–1948), Italian beatified of catholic churchElio Marchetti (born 1974), Italian race car driver and motorcycle racerFederico Marchetti (born 1983), Italian international football goalkeeperFilippo Marchetti (1831–1902), Italian opera composerGino Marchetti (born 1927), American professional football playerJohn W. Marchetti (1908-2003), radar pioneerLouis Marchetti (1920–1992), Italian illustrator and portrait painterMarco Marchetti (1528–1588), Italian painter of the late-Renaissance or Mannerist periodVictor Marchetti (born 1930), American intelligence agent and director in the CIA