The Manskin Indians were a tribe of American Indians who were a part of the Powhatan Confederacy in historic Virginia. From 1620-1750 they are referred to as "Manskin", on several maps, a name derived from Manaskunt. The numerous separate Indian villages shown in the Zuniga Map combined under the rule of Opechancanough, as a result of the pressures of losses from infectious disease and encroachment by the English colonists. The Manskin lived in a two-mile stretch of the Pamunkey River near where today Rt. 360 crosses the Pamunkey River in King William County, Virginia.
The Manskin are shown in almost all of the early maps of Virginia.
After 1750, the Manskin Indians disappeared as a tribe from the historical record. They show up in no lists of the tribes in inventories of the Powhatan Confederacy.
The Manskin name lives on in toponyms on maps today, whose origins were recognized only recently. The town of Manquin is located just north of The Island Field on Pampatike Farm, which is on Moncuin Creek. Both are anglicized versions of Manskin.