Mangano is a surname of Italian origin. Notable people with the surname include:
Anthony Mangano, American actor
Ed Mangano (born 1962), Nassau County Executive since 2010
Guy James Mangano (born 1930), New York politician and judge
Joy Mangano (born 1956), American inventor
Lawrence Mangano (1892–1944), American mobster
Philip Mangano (1898–1951), American mafioso
Silvana Mangano (1930–1989), Italian actress
Venero Mangano (born 1921), American mafioso
Vincent Mangano (1888–1951), American mafioso
Vittorio Mangano (1940–2000), Italian member of Cosa Nostra