Mangano is a surname of Italian origin. Notable people with the surname include:
Anthony Mangano, American actorEd Mangano (born 1962), Nassau County Executive since 2010Guy James Mangano (born 1930), New York politician and judgeJoy Mangano (born 1956), American inventorLawrence Mangano (1892–1944), American mobsterPhilip Mangano (1898–1951), American mafiosoSilvana Mangano (1930–1989), Italian actressVenero Mangano (born 1921), American mafiosoVincent Mangano (1888–1951), American mafiosoVittorio Mangano (1940–2000), Italian member of Cosa Nostra