Mandelstam or Mandelshtam (Russian: Мандельштам) is a Jewish surname which may refer to:
Leonid Mandelstam (1879–1944), Russian theoretical physicist
Mandel'shtam (crater), lunar crater named for Leonid Mandelstam
Nadezhda Mandelstam (1899–1980), Russian writer, wife of Osip Mandelstam
Osip Mandelstam (1891–1938), Russian poet
Stanley Mandelstam (1928–2016), South African-born particle physicist
Mandelstam variables, relativistically invariant representation for particle scattering, introduced by Stanley Mandelstam