Mancuso is a surname. An alternate spelling can be Mancusi. Notable people with the surname include:
Alejandro Mancuso, retired Argentine footballerAnna Mancuso, Canadian former politicianCiro Mancuso, Nevada-based drug dealer convicted of running a $140-million marijuana smuggling operationDavid Mancuso, American DJFilippo Mancuso, Italian judge and politicianFrank Mancuso Jr., movie producerGus Mancuso, catcher in Major League Baseball from 1928 to 1945Julia Mancuso, American alpine skier who won a gold medal at the 2006 Winter OlympicsLaurence Mancuso, founding abbot of the New Skete monasteryLeonardo Mancuso, Italian footballerNick Mancuso, Italian-Canadian cinema and stage actorRenee Mancuso, American bridge playerSalvatore Mancuso, Colombian paramilitary warlordThe fictional character Nick Mancuso, played by Robert Loggia in Favorite Son (1988) and Mancuso, F.B.I. (1989)