Mama Lo's was a popular and well-known soul food restaurant located in Gainesville, Florida. It was founded by, operated by, and named for Lorene "Mama Lo" Alexander in 1975 until her retirement in 2005. Located only a few blocks from the University of Florida, the establishment proved popular with students, townsfolk and travellers alike. It was also frequented by many local musicians such as Bo Diddley, Tom Petty and the Heartbreakers, The Stranger Band and Sister Hazel.
With reasonably-priced lunch dishes, UF alumni over the decades reminisce about their favorite Mama Lo's servings, such as chicken and rice, broccoli casserole, and sweet tea. It is said that through the Southern, home-style cooking Mama Lo served to loyal customers for over three decades, she put her four children through college in Gainesville. Mama Lo's was located at 618 NW 6th Street in Gainesville, Florida. Lorene "Mama Lo" Alexander died in 2007, at the age of 85.