Malonyl CoA O methyltransferase

Malonyl-CoA O-methyltransferase (EC 2.1.1.197, BioC) is an enzyme with systematic name S-adenosyl-L-methionine:malonyl-CoA O-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + malonyl-CoA ⇌ S-adenosyl-L-homocysteine + malonyl-CoA methyl ester

Malonyl-CoA O-methyltransferase is involved in an early step of biotin biosynthesis in Gram-negative bacteria.