Kalpana Kalpana (Editor)

Maleylacetoacetate isomerase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
5.2.1.2

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9023-75-0

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a maleylacetoacetate isomerase (EC 5.2.1.2) is an enzyme that catalyzes the chemical reaction

4-maleylacetoacetate 4-fumarylacetoacetate

Hence, this enzyme has one substrate, 4-maleylacetoacetate, and one product, 4-fumarylacetoacetate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 4-maleylacetoacetate cis-trans-isomerase. Other names in common use include maleylacetoacetic isomerase, maleylacetone isomerase, and maleylacetone cis-trans-isomerase. This enzyme participates in tyrosine metabolism and styrene degradation.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1FW1, 2CZ2, and 2CZ3.

References

Maleylacetoacetate isomerase Wikipedia