Maffei is an Italian surname. It may refer to:
Alessandro R. Maffei, Italian designer
Alessandro, Marquis de Maffei, Bavarian general
Andrea Maffei, Italian poet and librettist
Antonio Maffei, Italian art historian
Antonio Maffei, member of the Pazzi Conspiracy
Arturo Maffei, Italian athlete
Bernardino Maffei, Italian archbishop and cardinal
Clara Maffei, Italian lady of letters
Dan Maffei, United States Congressman representing the 25th Congressional District of New York
David Maffei, Accelerator Operator at Brookhaven National Laboratory, Operator of Maffei Sharpening Service New York
Fabrizio Maffei, Italian journalist and television presenter
Francesco Maffei, Italian painter
Francesco Maffei or Scipione Maffei, Italian archaeologist and man of letters
Fredric Maffei, Italian-American novelist
Giacomo Maffei, Italian American knife grinder who in 1914 founded Hub Grinding Service in Boston.
Giovanni Pietro Maffei (1533–1603), Italian Jesuit and writer.
Giovanni Andrea Maffei, Italian politician
Joseph Anton von Maffei, German industrialist
Leonard Maffei, Italian-American bicycle racer
Marcantonio Maffei, Italian cardinal
Michele Maffei, Italian fencer
Neal Maffei, London Based American Performance Artist
Nicola Maffei, Italian politician
Orazio Maffei, Italian cardinal
Paolo Maffei, Italian astrophysicist
Paolo Alessandro Maffei (1653 — 1716), Italian antiquarian humanist
Scipione Maffei, Italian playwright and literary critic
