Maddux is an English surname. It is a variant of Maddox. Notable people with the surname include:
Don Maddux (born 1940), American politician from OhioGreg Maddux (born 1966), American baseball pitcher and member of the Baseball Hall of Fame, brother of Mike MadduxJared Maddux (1911–1971), American politician from TennesseeMike Maddux (born 1961), American baseball pitcher and current pitching coach for the Texas Rangers, brother of Greg MadduxRoger Maddux (born 1948), American professor and mathematicianSam Maddux, Jr. (1915–1990), United States Air Force officerStu Maddux (born 1965), American writer and cinematographer