Species Human Entrez 822 | Human Mouse Ensembl ENSG00000042493 | |
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Aliases CAPG, AFCP, HEL-S-66, MCP, capping actin protein, gelsolin like External IDs MGI: 1098259 HomoloGene: 37523 GeneCards: CAPG | ||
Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.
Function
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.
References
Macrophage-capping protein Wikipedia(Text) CC BY-SA