Macomber is a surname that refers to:
Bart Macomber (1894–1971), American college football player
Debbie Macomber (b. 1948), American author of romance novels
James Macomber (b. 1944), American author or International Legal Thrillers
John D. Macomber (b. 1928), American businessman, President of the Export-Import Bank of the United States 1989–92
Joshua Mason Macomber (1811–1881), American educator and physician
Eisner v. Macomber, a 1920 decision by the United States Supreme Court
Macomber High School a former public vocational school in Toledo, Ohio.
