Machuca is a Spanish surname. Notable people with the surname include:
Alexis Machuca (born 1990), Chilean footballerAnggello Machuca (born 1984), Paraguayan footballerEdgar Machuca (born 1989), Paraguayan footballerJuan Machuca (born 1951), Chilean footballerManuel Machuca (1924–1985), Chilean footballerPedro Machuca (died 1550), Spanish architectSantiago Machuca (born 1929), Puerto Rican sport shooter