MacFarlane or Macfarlane is a surname derived from the Gaelic patronymic Mac Phàrlain (son of Parlan), shared by:
Alan Macfarlane (born 1941), professor of anthropological science at Cambridge UniversityAlan Brock MacFarlane (born c. 1920), lawyer, judge and political figure in British ColumbiaAlexander Macfarlane (disambiguation) (or Alex or MacFarlane), several peopleAlistair MacFarlane (born 1931), British electrical engineerAllison Macfarlane, chairman of the United States Nuclear Regulatory CommissionAmy MacFarlane (born 1974), former field hockey forwardAndrew Macfarlane (died 1819), Anglican clergyman who served as a bishop in the Scottish Episcopal ChurchAngus Hikairo Macfarlane, New Zealand, schoolteacher and educational psychologistBruce MacFarlane, Canadian lawyer, Crown prosecutor, legal scholar, and former federal and provincial Department of Justice officialCatharine Macfarlane (1877–1969), American obstetrician and gynecologistCharles Macfarlane (1799–1858), Scottish writerClarence W. Macfarlane (1858–1947), Hawaiian businessman and yachtsmanDave MacFarlane (1967–2013), Scottish professional football player who is best known for his time with KilmarnockDavid Macfarlane (born 1952), Canadian journalist, playwright and novelistDonald MacFarlane (1834-1926), Scottish preacherDonald Horne Macfarlane (1830–1904)Donna MacFarlane (born 1977), Australian middle distance and steeplechase runnerDorothy Macfarlane, an English cricketerDoug MacFarlane (1880–1965), English professional footballer who played for Barrow, Burnley and Tottenham HotspurDuncan Macfarlane (1827–1903), New Zealand grocer, merchant, government agent, farmer and magistrateEd Macfarlane (born 1984), singer, instrumentalist, producer, and the principal songwriter of Friendly FiresEdward C. Macfarlane (1848–1902), Hawaiian politician and businessmanEdith Mary Macfarlane (1871–1948), New Zealand community workerEve MacFarlane, New Zealand rowerGaynor Macfarlane, radio drama director and producer for BBC Radio Drama at Pacific Quay, GlasgowGeorge G. Macfarlane (1916–2007), engineer, scientific administrator and public servantGeorge W. Macfarlane (1849–1921), Hawaiian politician, royal chamberlain and businessmanGus MacFarlane (1925–1991), Canadian Liberal MP for Hamilton MountainHelen Macfarlane, a Scottish Chartist feminist journalist and philosopherJames Macfarlane (1844–1914), Scottish-born Australian politicianIan Macfarlane (disambiguation) (or MacFarlane), several peopleJean Macfarlane, American psychologistJohn MacFarlane (disambiguation) (or John Macfarlane), several peopleKarla MacFarlane, Canadian politicianKatie MacFarlane (born 1982), former American women's basketball player and a current U.S. Army intelligence officerKee MacFarlane (born 1947), Director of Children's Institute InternationalKris MacFarlane (born 1975), Canadian freelance drummerLaura Macfarlane, rock and roll musicianLes MacFarlane (1919–1986), former Australian politicianLorne MacFarlane (1904–1971), farmer and political figure in Prince Edward Island, CanadaLuke Macfarlane (born 1980), Canadian actorMalcolm MacFarlane (1853–1931), Scottish Gaelic scholar and songwriterMike Macfarlane (born 1964), former catcher in Major League BaseballNeil MacFarlane (footballer) (born 1977), Scottish professional footballerNeil Macfarlane (politician) (born 1936), British Conservative politician and former Minister for SportNorman Macfarlane, Baron Macfarlane of Bearsden (born 1926), British Conservative member of the House of LordsRab Macfarlane (1875–?), Scottish footballer in 1902 Scottish Cup FinalRachael MacFarlane (born 1976), voice actress and sister of Seth MacFarlaneRobert MacFarlane (disambiguation) (or Robert Macfarlane), several peopleRonald D. Macfarlane, distinguished professor of Chemistry at Texas A&M UniversitySandy MacFarlane (1878–?), Scottish football player and managerSeth MacFarlane (born 1973), American animator and voice actor, best known for his show Family GuyStewart MacFarlane (born 1953), figurative Australian painterThomas Macfarlane (1811–1885), 19th-century Member of Parliament from the Auckland Region, New ZealandWallace Macfarlane (W. Macfarlane) (1918-1999), author of speculative fiction published during the 1940s through 1970sWalter Scott MacFarlane (1896–1979), Canadian bard and soldier