Species Human Entrez 10608 | Human Mouse Ensembl ENSG00000123933 | |
Aliases MXD4, MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4 External IDs MGI: 104991 HomoloGene: 4712 GeneCards: MXD4 |
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
References
MXD4 Wikipedia(Text) CC BY-SA