Species Human Entrez 4520 | Human Mouse Ensembl ENSG00000188786 | |
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Aliases MTF1, MTF-1, ZRF, metal-regulatory transcription factor 1 External IDs MGI: 101786 HomoloGene: 4347 GeneCards: MTF1 | ||
Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.
Function
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).
References
MTF1 Wikipedia(Text) CC BY-SA