EC number 2.7.7.50 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 56941-23-2 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a mRNA guanylyltransferase (EC 2.7.7.50) is an enzyme that catalyzes the chemical reaction
GTP + (5')ppPur-mRNAThus, the two substrates of this enzyme are GTP and (5')ppPur-mRNA, whereas its two products are diphosphate and G(5')pppPur-mRNA.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:mRNA guanylyltransferase. Other names in common use include mRNA capping enzyme, messenger RNA guanylyltransferase, and Protein 2.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1CKM, 1CKN, 1CKO, 1P16, and 2C46.
References
MRNA guanylyltransferase Wikipedia(Text) CC BY-SA