Samiksha Jaiswal (Editor)

MRNA (guanine N7 ) methyltransferase

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EC number
  
2.1.1.56

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
56941-25-4

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

MRNA (guanine-N7-)-methyltransferase

In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + G(5')pppR-RNA ⇌ S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.

In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.

Nomenclature

The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:

  • messenger ribonucleate guanine 7-methyltransferase,
  • guanine-7-methyltransferase,
  • messenger RNA guanine 7-methyltransferase, and
  • S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.
  • cap MTase

    • References

    MRNA (guanine-N7-)-methyltransferase Wikipedia
    (Text) CC BY-SA