MRNA (guanine N7 ) methyltransferase

Updated on Oct 02, 2024

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EC number 2.1.1.56 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 56941-25-4 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + G(5')pppR-RNA ⇌ S-adenosyl-L-homocysteine + m₇G(5')pppR-RNA (mRNA containing an N⁷-methylguanine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.

In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.

Nomenclature

The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:

messenger ribonucleate guanine 7-methyltransferase,

guanine-7-methyltransferase,

messenger RNA guanine 7-methyltransferase, and

S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.

cap MTase

References

MRNA (guanine-N7-)-methyltransferase Wikipedia

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