MRAP2

Melanocortin 2 receptor accessory protein 2 is a protein that in humans is encoded by the MRAP2 gene. MRAP2 interacts directly with melanocortin 4 receptor (MCR4).

Knockout of the Mrap2 gene in mice leads to severe obesity. In addition, a rare mutation of the MRAP2 gene in humans leads to severe, early-onset obesity.