Species Human Entrez 4326 | Human Mouse Ensembl ENSG00000198598 | |
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Aliases MMP17, MT4-MMP, MMP-17, MT4MMP, MTMMP4, matrix metallopeptidase 17 External IDs MGI: 1346076 HomoloGene: 22669 GeneCards: MMP17 | ||
Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 (MT-MMP 4) is an enzyme that in humans is encoded by the MMP17 gene.
Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP2 by cleavage.
In melanocytic cells MMP17 gene expression may be regulated by MITF.