Species Human Entrez 23195 | Human Mouse Ensembl ENSG00000112159 | |
Aliases MDN1, Rea1, midasin AAA ATPase 1 External IDs MGI: 1926159 HomoloGene: 39689 GeneCards: MDN1 | ||
MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene.
Model organisms
Model organisms have been used in the study of MDN1 function. A conditional knockout mouse line, called Mdn1tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and three significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an increased susceptibility to bacterial infection.