Girish Mahajan (Editor)

MAP kinase kinase kinase

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EC number
  
2.7.11.25

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
146702-84-3

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

MAP kinase kinase kinase

MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.

In humans there are at least 19 genes:

  • MAP3K1 (aka MEKK1)
  • MAP3K2
  • MAP3K3 (aka MEKK3)
  • MAP3K4
  • MAP3K5 (aka ASK1)
  • MAP3K6 (aka ASK2)
  • MAP3K7 (aka MEKK7) (aka TAK1)
  • MAP3K8 (aka TPL2 or Tpl2)
  • MAP3K9
  • MAP3K10
  • MAP3K11 (aka MEKK11) (aka MLK3)
  • MAP3K12 (aka MUK)
  • MAP3K13 (aka LZK)
  • MAP3K14
  • MAP3K15
  • MAP3K16 (aka TAO1 or TAOK1)
  • MAP3K17 (aka TAO2 or TAOK2)
  • RAF1
  • BRAF
  • ARAF
  • ZAK (aka MLTK)

    • Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).

    MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).

    MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.

    MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).

    References

    MAP kinase kinase kinase Wikipedia
    (Text) CC BY-SA