Lytton is a surname. Notable people with the surname include:
Antony Bulwer-Lytton, Viscount Knebworth (1903–1933), British pilot and politician
Lady Constance Lytton (1869–1923), British suffragette activist, writer, speaker and campaigner
David Lytton-Cobbold, 2nd Baron Cobbold (born 1937), English banker and country house manager
Edward Bulwer-Lytton, 1st Baron Lytton (1803–1873), English novelist, poet, playwright, and politician
Elizabeth Barbara Lytton (1773–1843), foremother of the Bulwer-Lytton family
Sir Henry Lytton (1865–1936), English actor and singer
Henry Lytton-Cobbold (born 1962), English screenwriter and country house manager
John Lytton, 5th Earl of Lytton (born 1950), British surveyor and House of Lords member
Judith Blunt-Lytton, 16th Baroness Wentworth (1873–1957), British peer, Arabian horse breeder and real tennis player
Louisa Lytton (born 1989), English actress
Neville Bulwer-Lytton, 3rd Earl of Lytton (1879–1951), British military officer and artist
Noel Lytton, 4th Earl of Lytton (1900–1985), British Army officer and writer
Paul Lytton (born 1947), English jazz percussionist
Philip Lytton, pseudonym of Charles Ernest Phillips (died 1949), Australian actor and theatrical entrepreneur
Robert Bulwer-Lytton, 1st Earl of Lytton (1831–1891), English statesman and poet, Viceroy of India during the Great Famine of 1876–78
Rogers Lytton (1867–1924), American film actor
Sir Roland Lytton (or Rowland Litton, 1561–1615), English lawyer and politician
Sir Rowland Lytton (c.1615–1674), English politician
Rosina Bulwer Lytton (1802–1882), English novelist and essayist
Victor Bulwer-Lytton, 2nd Earl of Lytton (1876–1947), British politician and colonial administrator
Sir William Lytton (1586–1660), English politician
Fictional characters:
Lytton (Doctor Who), recurring character in BBC science fiction series Doctor Who
Vanessa Lytton in BBC medical drama series Holby City
