Lyttle is a surname. Notable people with the surname include:
Joan Sylvia Lyttle Birman (born 1927), American mathematician, specializing in braid theory and knot theoryBradford Lyttle, prominent pacifist and peace activist, organizer with the Committee for Non-Violent ActionChris Lyttle (born 1981), politician in Northern IrelandDavid Lyttle (born 1984), musician, producer, songwriter, composer and record label owner from Northern IrelandDes Lyttle (born 1971), English former footballer turned football managerFoggy Lyttle, (born 1944), guitarist, best known for his work with Van MorrisonJim Lyttle (born 1946), former major league baseball player from Hamilton, OhioKevin Lyttle (born 1976), soca artist from Saint Vincent and the GrenadinesPaul Lyttle (age 38), Canadian-American curlerSancho Lyttle (born 1983), professional basketball player born in Saint Vincent and the GrenadinesTanya Katherine Rosales Lyttle (born 1981), Filipina telenovela and film actressTommy Lyttle (1939–1995), high-ranking Northern Irish loyalist during the TroublesWesley Guard Lyttle (1844–1896), Irish newspaper publisher, writer and editor