Lyles is a surname. Notable people with the surname include:
A. C. Lyles (1918–2013), American film producer
Aubrey Lyles (1883–1932), American songwriter, lyricist, and vaudeville performer
Jordan Lyles, American baseball player
Kathryn Lyles, American stage actor
Lenny Lyles (1936–2011), American football player
Lester Lyles (born 1946), United States Air Force general
Lester Lyles (American football) (born 1962), American football player
Nate Lyles (born 1985), American football player
Robert Lyles (born 1961), American football player
Trey Lyles (born 1995), Canadian–American basketball player
