Lyles is a surname. Notable people with the surname include:
A. C. Lyles (1918–2013), American film producerAubrey Lyles (1883–1932), American songwriter, lyricist, and vaudeville performerJordan Lyles, American baseball playerKathryn Lyles, American stage actorLenny Lyles (1936–2011), American football playerLester Lyles (born 1946), United States Air Force generalLester Lyles (American football) (born 1962), American football playerNate Lyles (born 1985), American football playerRobert Lyles (born 1961), American football playerTrey Lyles (born 1995), Canadian–American basketball player