Luper is a surname. Notable people with the surname include:
Clara Luper (born 1923), civic leader, retired schoolteacher, and a pioneering leader in the American Civil Rights Movement
Curtis Luper (born 1966), American college football assistant coach at Auburn University
James Luper, Oregon pioneer
Tulse Luper, fictional ornithologist, created by Peter Greenaway
Luper, Oregon, stop on the Oregon and California Railroad near Junction City, Oregon
Luper Cemetery, pioneer cemetery near Junction City, Oregon