Lovastatin nonaketide synthase

In enzymology, lovastatin nonaketide synthase (EC 2.3.1.161) is an enzyme that catalyzes the chemical reaction

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H⁺, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO₂, NADP⁺, S-adenosyl-L-homocysteine, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).