EC number 2.3.1.161 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 235426-97-8 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, lovastatin nonaketide synthase (EC 2.3.1.161) is an enzyme that catalyzes the chemical reaction
acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionineThe 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H+, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO2, NADP+, S-adenosyl-L-homocysteine, and H2O.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).
References
Lovastatin nonaketide synthase Wikipedia(Text) CC BY-SA