Losh is a surname. Notable people with the surname include:
Barbi Losh (born 1963), American model and actress, Miss Florida USA 1985
Elizabeth Losh, media theorist
James Losh (1763–1833), English lawyer, reformer and unitarian
Sarah or Sara Losh (1785–1853), English architect and designer
William Losh (1770–1861), English chemist and industrialist credited with introducing the Leblanc process
LoSH also stands for:
Legion of Super-Heroes