Lorene is a given name. Notable people with the name include:
Lorene Cary (born 1957), American author, educator, and social activist
Lorene Ramsey, pioneer in women's sports, one of the most successful college coaches of all time
Lorene Rogers (1914–2009), American biochemist and educator, president of the University of Texas at Austin in the 1970s
Lorene Scafaria, American screenwriter, playwright, actor and singer known for her work on the 2008 film Nick and Norah's Infinite Playlist
Lorene T. Coates, Democratic member of the North Carolina General Assembly
Lorene Yarnell of Shields and Yarnell, American mime team formed in 1972