Lorene is a given name. Notable people with the name include:
Lorene Cary (born 1957), American author, educator, and social activistLorene Ramsey, pioneer in women's sports, one of the most successful college coaches of all timeLorene Rogers (1914–2009), American biochemist and educator, president of the University of Texas at Austin in the 1970sLorene Scafaria, American screenwriter, playwright, actor and singer known for her work on the 2008 film Nick and Norah's Infinite PlaylistLorene T. Coates, Democratic member of the North Carolina General AssemblyLorene Yarnell of Shields and Yarnell, American mime team formed in 1972