Looney is a surname. Notable people with the surname include:
Andy Looney (born 1963), game designer
J. Thomas Looney (1870–1944), originator of the Oxfordian theory regarding the authorship of Shakespeare's plays
Jim Looney (born 1957), American football player
Joe Don Looney (1942–1988) American football player
John Patrick Looney (1867–1947), gangster in the Rock Island, Illinois area during the early 1900s
John Looney (chief) (died 1838), chief of the Cherokee nation
Kevon Looney (born 1996), American basketball player
Michael O'Looney (born 1965) MD of Barclays USA, and former TV anchor
William R. Looney III (born 1949), former Commander, Air Education and Training Command, United States Air Force
