Loewe additivity

In Pharmacology, Loewe Additivity is one of several common reference models used for measuring the effects of drug combinations.

Loewe additivity is based on the idea that an agent should not have synergistic interactions with itself or like agents.

To better understand the model of Loewe Additivity, an additive drug could be shown with a basic formula:

If drug x and drug y are similar drugs, a dose of x and y (at equal concentration) will replicate the effect of double the dose (2x), of either drug.

IF x=y , THEN x+y → 2x.

The reverse of this scenario is known as hyper-antagonism.