Lobe is a surname. Notable people with the surname include:
Adolf Lobe (1860–1939), German jurist and member of the Reichstag in the Weimar Republic
Bill Lobe (1912–1969), American baseball player and coach
Jim Lobe (born 1949), American journalist
Kārlis Lobe (1895–1985), Latvian collaborationist with the Nazis
Mira Lobe (1913–1995), Austrian author
Robert Lawrance Lobe (born 1945), American sculptor